Cardiac protective effect and mechanism of remote ischemic preconditioning

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400088680

Enrollment

Unknown

Registered

2024-08-23

Start date

2024-09-10

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial ischemia-reperfusion injury

Interventions

RIPC Group:Subjects received 5-minute ischemia / 5-minute reperfusion of 180mmHg and 4 cycles of remote ischemic preconditioning therapy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) The subjects voluntarily participate in the experiment and sign the informed consent; 2) The age of 18 years old or above, regardless of gender; 3) Healthy subjects should have no underlying diseases; Subjects with comorbidity should be clinically diagnosed with hypertension or/and diabetes (no other comorbidity); 4) Did not participate in clinical trials within 3 months before the trial; 5) No surgery is planned in the near future.

Exclusion criteria

Exclusion criteria: 1) Arm fracture, skin injury or infection; 2) There is limb nerve injury; 3) Limb placement PICC, arteriovenous fistula and other devices that affect armband placement; 4) There are basic vascular lesions and poor blood supply at the extremities; 5) Limb thrombosis.

Design outcomes

Primary

Measure	Time frame
troponin-I;	—

Secondary

Measure	Time frame
troponin-T;IL-1ß;CK-MB;myoglobin;TNF-a;IL-10;Liquid chromatography–mass spectrometry;	—

Countries

China

Contacts

Public ContactZhu Tao

West China Hospital of Sichuan University

739501155@qq.com+86 189 8060 1552

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026