Sedation of patients in the ICU
Conditions
Interventions
The Cipepofol Group:The Cipepofol will be administered for sedation
The Propofol Group:The Propofol will be administered for sedation
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ICU patients requiring mechanical ventilation; 2.The target RASS ranged from 0 to -3, and the expected sedation time was more than 24 hours after randomization; 3. 18 years old = age < 80 years old; Gender is unrestricted; 4. 18 kg/m2 = BMI = 30 kg/m2; 5. Patients or their family members have a full comprehension of the purpose and significance of this trial, voluntarily participate in this clinical trial, and sign an informed consent.
Exclusion criteria
Exclusion criteria: 1. Contraindications or allergies to the study drugs; 2. Acute severe neurological illness and any other conditions that interfere with the RASS assessment; 3. Cardiovascular diseases: bradycardia and/or heart rate = 50 beats/min requiring drug treatment; Degree II-III atrioventricular block (excluding patients with pacemakers); Acute and chronic myocarditis; 4. Acute hepatitis or severe liver dysfunction; 5. Chronic kidney disease patients with glomerular filtration rate GFR = 30 mL/(min * 1.73 m2); 6. Patients with high paraplegia and general paralysis; 7. Patients with uncontrolled hemodynamics (such as patients with systolic blood pressure less than 90 mmHg despite appropriate intravenous fluids and continuous infusion of two vasopressors, or patients with shock, etc.); 8. Previous history of abuse of nerve drugs and narcotic drugs; History of alcohol abuse and long-term use of psychotropic drugs within 3 months before the screening period; 9. Pregnancy and lactation; 10. Participation in other drug clinical trials within 1 month before screening; 11. Any other circumstances in which the patient was judged by the investigator to be ineligible for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The compliance rate of early sedation;The usage of study drug;The duration of Mechanical ventilation;Extubation time;Recovery Time to Full Consciousness;Length of ICU stay;Patient survival;The usage of vasoactive drugs;Changes in triglyceride levels; | — |
Countries
China
Contacts
Public ContactYan Kang
West China Hospital, Sichuan University
Outcome results
None listed