respiration
Conditions
Interventions
Oliceridine group:Anesthesia induction with oliceridine followed by ciprofol.
Fentanyl group:Anesthesia induction with fentanyl followed by ciprofol.
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65; 2. ASA1-III; 3. Patients undergo fibrobronchoscopy under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications for bronchoscopy; 2. Patients with difficult airway; 3. Patients with study drug allergy; 4, patients with severe hypertension (systolic blood pressure =180mmHg, or diastolic blood pressure =110mmHg); 5. Patients with severe arrhythmia; 6. Patients with severe cardiac insufficiency classified as New York Heart Association (NYHA) Level III or above; 7. Patients with liver and kidney dysfunction characterized by abnormal biochemical indexes of liver and kidney function; 8. Patients whose preoperative state of consciousness is difficult to determine; 9. Patients with a history of psychotropic drug use; 10. Patients who meet any other conditions that the investigators deem unsuitable for inclusion in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tracheal response rate during bronchoscopy examination;Respiratory depression rate during bronchoscop; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of vasoactive drugs;Dose of anesthesia;Time of surgery and anesthesia;Patient comfort level;Operator comfort level;Vital signs(blood pressure, HR, SpO2, RR, BIS);Completion of FOB; | — |
Countries
China
Contacts
Public ContactXuehai Guan
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed