Gynecological diseases in obese patient
Conditions
Interventions
Group N:deep neuromuscular blockade and low-pressure pneumoperitoneum combined with lung-protective ventilation strategy was used during operation
Group C:moderate neuromuscular blockade and high-pressure pneumoperitoneum combined with conventional intermittent positive pressure ventilation mode
Sponsors
Affiliated Boai Hospital of Zhongshan, Southern Medical University
Eligibility
Sex/Gender
Female
Age
24 Years to 64 Years
Inclusion criteria
Inclusion criteria: ?Patients who met the criteria for gynecological elective laparoscopic surgery ?Patients aged 24-64 years and able to tolerate surgery and anesthesia ?ASA(American society of anesthesiologists)I~II ?BMI=30kg/m2 ?The functions of heart, lung, liver, brain and kidney are normal; No previous history of brain injury, brain surgery or epilepsy ?Laparoscopic surgery was performed under general anesthesia ?volunteered to participate in this study and signed informed consent forms before operation
Exclusion criteria
Exclusion criteria: ?Patients with neuromuscular functional defect such as myasthenia gravis and those who take drugs affecting neuromuscular conduction function for a long time ?Patients with a history of cardiac insufficiency or heart failure who cannot tolerate neostigmine and atropine ?Hepatic and renal insufficiency ?Combined with pulmonary infection and tuberculosis;Suffer from chronic lung obstruction,bronchial asthma and other diseases ?Patients who cannot accept the monitoring of neuromuscular block depth
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of pulmonary complications (PPCs) on the 1st, 3rd, 7th, and 30th day after the operation and cumulative incidence within 30 days after the operation in both groups;ambulation time ;discharge time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Abdominal pain score on the 1st and 2nd day after the operation;Operator's satisfaction with exposure of operation field;Mean arterial pressure (MAP), Pulse rate (HR) and pressure in airway (Paw) were recorded before pneumoperitoneum (T0) and 1 hour after pneumoperitoneum (T1).;arterial blood gas analysis 1 hour after pneumoperitoneum (T1).;The recovery time of the train of four ratio to 0.7, 0.9;recovery time; | — |
Countries
China
Contacts
Public ContactLuo Guozhan
Department of Anesthesiology.Affiliated Boai Hospital of Zhongshan, Southern Medical University
Outcome results
None listed