tuberculosis
Conditions
Interventions
Group with isoniazid and rifapentine:None
Group with isoniazid and rifampicin:None
Group with VACCE :None
Group with health education:None
Sponsors
School of Public Health, Fudan University
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.During the infectious period of the patient (3 months before diagnosis -14 days after starting treatment), close contacts within the same household living with a pathogen positive pulmonary tuberculosis patient for more than 7 days, or continuous contact for 8 hours or cumulative contact for 40 hours in the same confined space; 2.16 – 60 years old 3.Recombinant Mycobacterium Tuberculosis Fusion Protein (EC) or Interferon-Gamma Release Assay (IGRA) positive 4.No clinical signs and symptoms of active disease 5.No active TB-like lesions on the chest radiograph 6. Sign the informed consent and be willing to be enrolled in the follow-up study.
Exclusion criteria
Exclusion criteria: 1.Having underlying disease or being receiving the treatment against hepatitis, hematological and psychological disorders. 2.Considered inappropriate to receive preventive therapy from doctors 3.Not capable of adhering to the preventive therapy 4. Diagnosed with tuberculosis and completed standard treatment within 5 years before the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence within 2 years after start of treatment;Safety during the treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| plasma concentrations;Multi-omics biomarker; | — |
Countries
China
Contacts
Public ContactYi Hu
Fudan University
Outcome results
None listed