respiratory failure
Conditions
Interventions
HFV-CMV:When the ventilator parameters are lowered to HFV weaning standards, transitioning from high-frequency to conventional mechanical ventilation.
HFV-HFV: When the ventilator parameters are decreased to HFV weaning standards, decrease the mean airway pressure.
Sponsors
West China Second University Hospital,Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Newborns using HFV. [1] Patients with or at high risk of air leak syndrome requiring IMV will be directly ventilated with HFV. [2] Patients primarily under CMV will be switched to HFV if the following criteria are met: PIP > 25cmH2O, PEEP > 8cmH2O, or FiO2 > 60% and the patient is unable to maintain SpO2 > 90% and pH > 7.25, PCO2 = 60mmHg. 2. The newborn is eligible for weaning from HFV: [1] Pmean = 12 cmH2O, FiO2 = 40%, pH = 7.30, PCO2= 55 mmHg. [2] Stable vital signs. [3] Absence of severe metabolic acidosis and active pulmonary hemorrhage.
Exclusion criteria
Exclusion criteria: 1. Patients with untreated air leak syndrome. 2. The guardian signed and refused to participate in the trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| oxygen extraction fraction;heart rate;blood pressure;The incidence and severity of IVH and PVL; | — |
Primary
| Measure | Time frame |
|---|---|
| cerebral oxygen saturation; | — |
Countries
China
Contacts
Public ContactTao Xiong
West China Second University Hospital,Sichuan University
Outcome results
None listed