postoperative cognitive dysfunction
Conditions
Interventions
Remimazolam Group(Group R):Anesthesia induction: etomidate (2-3mg/kg), rocuronium (0.6-1mg/kg), sufentanil (2-3ug/kg) and remazolam (0.3mg/kg). After endotracheal intubation, respiratory parameters we
Dexmedetomidine Group (Group D):Pump 1µg/kg of dexmedetomidine within 10 minutes before induction
Anesthesia induction: etomidate (2-3mg/kg), rocuronium (0.6-1mg/kg) and sufentanil (2-3ug/kg). After e
Saline Group(Group C):Anesthesia induction: etomidate (2-3mg/kg), rocuronium (0.6-1mg/kg), sufentanil (2-3ug/kg) and saline (5ml). After endotracheal intubation, respiratory parameters were adjusted t
Sponsors
Affiliated Hospital of Jining Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: ?Patients with surgical indications for coronary artery bypass surgery ?Cardiac function grade I-II ? aged 65–80 years old
Exclusion criteria
Exclusion criteria: ?preoperative Mini-mental State Examination (MMSE) or Montreal Cognitive Assessment (MoCA) cognitive dysfunction (preoperative scores =17 for illiterate, =20 for primary, =22 for secondary, and =23 for university) ?severe visual and hearing impairment that prevents communication ?History of allergy to anaesthetic ?Patients with history of active internal bleeding, acute/subacute cerebral infarction and brain trauma ?Severe liver and kidney dysfunction: Child-Pugh grade C and uremia stage ?endotracheal tube cannot be removed on the first day after surgery ?subjects requesting termination of the test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score;MoCA score;A-ß;S-100ß;NSE; | — |
Countries
China
Contacts
Public ContactRan Kong
Affiliated Hospital of Jining Medical University
Outcome results
None listed