Cerebral small vessel disease
Conditions
Interventions
CSVD group:None
Healthy control group:None
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Experimental Group: Age between 18 to 80 years old; Meeting the diagnostic criteria of the "Chinese Guidelines for the Diagnosis and Treatment of Cerebral Small Vessel Disease 2020"; Have undergone examinations such as cranial MRI, fundus photography, OCT, and OCTA. Informed consent has been signed by the patient or their family. Control Group: Primarily including individuals from the physical examination population of inpatients in our hospital (aged 18 to 80 years old); cranial MRI showed no abnormalities. These individuals showed no impairment in any cognitive domain during the cognitive assessment process; They have no history of cerebrovascular diseases, neurodegenerative diseases, or ocular abnormalities, and have normal vision.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Both Experimental and Control Groups: (1)History of ocular surgery or primary ocular diseases, such as retinal choroiditis, cataract, glaucoma, posterior vitreous detachment, preretinal membrane, macular degeneration, optic nerve disease, severe diabetic or hypertensive retinopathy; (2)Presence of potential cardiovascular diseases, such as atrial fibrillation, infective endocarditis, valvular heart disease; (3)Large area cerebral infarction; (4)Intracranial hemorrhage; (5)Systemic diseases, such as shock or tumors; (6)Neurological diseases, such as Parkinson's disease, multiple sclerosis, or Alzheimer's disease; (7)Mental disorders, such as hallucinations or depressive disorders; (8)Alcohol or drug abuse; (9)Language disorders; (10)Contraindications for MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fundus photography parameters;Optical coherence tomography (OCT) parameters;OCT angiography (OCTA) parameters;Cranial MRI parameters.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transcranial Doppler (TCD) parameters; | — |
Countries
China
Contacts
Public ContactChu Lan,Lin Xiang
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed