Bleeding during perioperative cardiac surgery
Conditions
Interventions
Aminocaproic acid high dose group:Aminocaproic acid 80mg/kg, 20 minutes to pump the load, and then at a constant rate of 30mg/Kg/h per hour
Aminocaproic acid low dose group:Aminocaproic acid 60mg/kg, 20 minutes to pump the load, and then at a constant rate of 30mg/Kg/h per hour
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-80 years old; 2) Undergoing elective valve replacement/plasty (requiring cardiopulmonary bypass); 3) Sign informed consent;
Exclusion criteria
Exclusion criteria: 1) Previous history of cardiac surgery; 2) Severe liver dysfunction before operation; 3) Preoperative coagulation disorders, including inherited or acquired coagulation factor deficiency, thrombocytopenia, platelet dysfunction, or other bleeding disorders; 4) Take warfarin before surgery, INR>1.2 (or the upper limit of normal) after withdrawal; 5) Clopidogrel was discontinued for less than 5 days before surgery, and low molecular weight heparin was discontinued for less than 12 hours; 6) Allergy to allogeneic blood products. 7) Patients with preoperative cognitive dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding amount within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of allogeneic red blood cell transfusions within 7 days after surgery (including intraoperative);ICU stay; | — |
Countries
China
Contacts
Public ContactXiaojie Liu
Affiliated Hospital of Qingdao University
Outcome results
None listed