schizophrenia
Conditions
Interventions
Working memory training group:Working memory training+Sham Intermittent theta burst stimulation treatment + Routine clinical interventions
Control group:Sham Intermittent theta burst stimulation treatment + Routine clinical interventions
Intermittent theta burst stimulation and work memory group :Intermittent theta burst stimulation and Work memory training + Routine clinical interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-55 years old; 2. Conforming to the diagnostic criteria for schizophrenia in the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders, diagnosed by a psychiatrist based on MINI plus v 5.0, with a course of at least 1 year; 3. Patients who have received stable dose medication in the past month and have significant negative symptoms: the negative symptom score on the Positive and Negative Symptom Scale (PANSS) is not less than 20, and at least one item on the PANSS negative symptom scale is >= 4 points; 4. All patients have stable clinical conditions and are able to provide informed consent, and all participants have obtained written informed consent; 5. Take second-generation antipsychotic drugs, such as Olanzapine and Quetiapine.
Exclusion criteria
Exclusion criteria: 1. Merge with other brain diseases; 2. Severe physical conditions, including severe liver, kidney, cardiovascular and other diseases; 3. History of alcohol and drug abuse; 4. Individual or family medical history of other mental diseases, including Personality disorder and mental retardation; 5. People with metal clips, plates, or any other metal objects on their heads; 6. Receiving electroconvulsive treatment within 6 months; 7. The evaluation process do not cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychopathological status;Negative symptoms ;Brain function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function;Emotional state;Social function; | — |
Countries
China
Contacts
Public ContactZhang Wei
West China Hospital, Sichuan University
Outcome results
None listed