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Effect of thoracic epidural analgesia on intestinal microflora in patients with severe hyperlipidemic pancreatitis: a cohort study

Effect of thoracic epidural analgesia on intestinal microflora in patients with severe hyperlipidemic pancreatitis: a cohort study

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400088574
Enrollment
Unknown
Registered
2024-08-21
Start date
2024-01-24
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pancreatitis

Interventions

Sponsors

The First Affiliated Hospital of Zunyi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) 18 years old =65 years old, admitted to ICU for more than 24 hours, according to clinical data, hematological indicators and imaging examination, confirmed diagnosis of severe acute hyperlipidemic pancreatitis; 2) Patients or family members can understand the study protocol and are willing to participate in the study, and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1) The prothrombin time was <60%, the platelet count was <75 G/L, and the interruption time of heparin anticoagulation therapy was less than 8 hours; 2) Active infection of the central nervous system, history of back surgery with dural space surgery, suspected or confirmed intracranial hypertension; 3) Refractory circulatory shock after appropriate resuscitation; 4) Known allergy to lidocaine, ropivacaine, or nalbuphine; 5) Use of monoamine oxidase inhibitors within the past 15 days; 6) Patients with incomplete medical records; 7) Patients with a history of chronic intestinal disease; 8) Patients who have used antibiotics, probiotics or gastrointestinal bleeding in the past 4 weeks.

Design outcomes

Primary

MeasureTime frame
Microbial community, genus, and type;

Secondary

MeasureTime frame
Length of ICU stay;Total hospitalization days;28-day mortality rate;

Countries

China

Contacts

Public ContactBao Fu

The First Affiliated Hospital of Zunyi Medical University

fubao0607@126.com+86 187 9812 1970

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026