None
Conditions
Interventions
Medium-dose group:Esketamine+Midazolam oral solution mixture is taken orally+2 µg/kg dexmedetomidine nasal drops
Control group:Dextrose taken orally+3 µg/kg dexmedetomidine nasal drops
Low-dose group:Esketamine+Midazolam oral solution mixture is taken orally+1 µg/kg dexmedetomidine nasal drops
High-dose group:Esketamine+Midazolam oral solution mixture is taken orally+3 µg/kg dexmedetomidine nasal drops
3 µg/kg dexmedetomidine nasal drops
Sponsors
Xi'an International Medical Center Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: aged 1-6 years with ASA class I-II who were scheduled for outpatient MRI under medium-deep sedation
Exclusion criteria
Exclusion criteria: Allergy to the study drug; Suffering from systemic disease with severe organ dysfunction; Those who have a history of intellectual disability or cognitive impairment and are unable to cooperate; Guardian's refusal to participate in the study; Other reasons that, in the opinion of the investigator, preclude continuation of treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of MRI sedation in children; | — |
Secondary
| Measure | Time frame |
|---|---|
| Children's behavior scores at the time of drug administration;Children's modified sedation Ramsay score every 5 minutes after taking the drug;Time from initiation of dosing to entry into the examination room;Maximum depth of sedation score;The child maintained the behavior score when the child was separated from the parents;Wake time and adverse effects;Radiologist satisfaction and parent satisfaction; | — |
Countries
China
Contacts
Public ContactLi Siyuan
Xi'an International Medical Center Hospital
Outcome results
None listed