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Effect of intravenous administration of lidocaine on the ED50 and ED95 of propofol induction dose during gastroscopy in patients with high risk of Obstructive sleep apnea syndrome

Effect of intravenous administration of lidocaine on the ED50 and ED95 of propofol induction dose during gastroscopy in patients with high risk of Obstructive sleep apnea syndrome

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088569
Enrollment
Unknown
Registered
2024-08-21
Start date
2024-08-21
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing painless gastroscopy

Interventions

control group:Normal saline+propofol
lidocaine group:lidocaine+propofol

Sponsors

Beijing Friendship Hospital of Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1) Patients over 18 years old with ASA grade I-III in our hospital who intend to undergo painless gastroscopy; 2) Stop-Bang = 3 points;

Exclusion criteria

Exclusion criteria: 1) Patients who do not cooperate and cannot obtain informed consent; 2) Patients allergic to propofol and lidocaine; 3) Patients with severe central nervous system diseases (cranial hypertension, etc.), history of mental illness, mental illness, or preoperative cognitive dysfunction; 4) long-term use of sedative hypnotic drugs or sedative analgesic drugs; 5) History of severe arrhythmia; People with poorly controlled or untreated hypertension; 6) Acute pharyngitis/tonsillitis, with a history of symptoms within one week; 7) Pneumonia or SpO2 (pulse oximetry) < 90% (no oxygen intake); 8) Untreated or undertreated hyperthyroidism; 9) Pregnant or lactating patients; 10) Participating in other clinical studies in the past 3 months; 11) Conditions deemed unsuitable for inclusion by the anesthesiologist.

Design outcomes

Primary

MeasureTime frame
The ED50 and ED95 of propofol;

Countries

China

Contacts

Public ContactQi Xiuru

Beijing Friendship Hospital, Capital Medical University

m18310177985@163.com+86 183 1017 7985

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026