delayed facial palsy
Conditions
Interventions
Intervention Group:Day of surgery, postoperative day 1, postoperative day 2: dexamethasone injection 10mg qd vgtt
Postoperative days 3-9: Prednisone acetate tablets 30mg qd po
Postoperative days 10-16
Control Group:Postoperative days 2-16: vitamin B1 tablet 10mg tid po
Postoperative day 2-16: methylcobalamin tablet 0.5mg tid po
Sponsors
Xinhua Hospital Affilated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for primary hemifacial spasm; 2. Aged 18-80 years old; 3. Undergo facial nerve microvascular decompression surgery for the first time; 4. Willing to participate in this clinical study and sign the informed consent form for the clinical study.
Exclusion criteria
Exclusion criteria: 1. Facial paralysis within 24 hours after surgery; 2. Allergy to glucocorticoids; 3. contraindications to glucocorticoid application (if there is a history of gastric and duodenal ulcers, glaucoma, hypertension, thrombosis, myocardial infarction, visceral surgery, electrolyte metabolism abnormalities, etc., this will be judged on a case-by-case basis by the clinician); 4. history of ipsilateral facial paralysis; 5. the presence of intracranial or extracranial organic lesions that may cause ipsilateral facial paralysis; 6. previous ipsilateral nerve-related surgery; 7. cognitive impairment, dementia, severe mental illness; 8. pregnant or breastfeeding women 9. poor patient compliance and inability to co-operate with medication; 10. participation in other clinical studies within 3 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of cases of delayed facial paralysis between 24 hours and 30 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Facial Disability Index (FDI) Scale;Facial nerve function (the House-Brackmann system); | — |
Countries
China
Contacts
Public ContactLi Shiting
Xinhua Hospital Affilated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed