Chronic cough
Conditions
Interventions
Intervention group:Galactooligosaccharide oral dose 8g per day
Control group:Maltodextrin oral 8g per day
Sponsors
Shanghai Jingan District Zhabei Central Hospital
Eligibility
Sex/Gender
All
Age
4 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Children aged 4 to 17 years. 2. Persistent cough symptoms > 4 weeks. 3. Cough is the main or only complaint, and there is no obvious abnormality in chest X-ray. 4. Exclude chronic cough caused by other reasons such as congenital respiratory diseases, foreign body aspiration, bronchial asthma, bronchiectasis, etc. 5. Obtain written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with abdominal pain, bloating, diarrhea, vomiting or digestive system diseases. 2. Patients with nutrition and nutritional disorders, primary or secondary immunodeficiency diseases, autoimmune diseases, genetic metabolic diseases, and endocrine diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FeNO; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cough symptom score;Visual Analogue Scale;Leicester quality of life rating;Fecal microbial diversity analysis;Peripheral blood cell analysis;Peripheral blood CRP level; | — |
Countries
China
Contacts
Public ContactLiu Danyang
Shanghai Jingan District Zhabei Central Hospital
Outcome results
None listed