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A prospective, randomized, multicenter study on the safety and efficacy of combined mapping using Advisor HD Grid multipolar catheter and conventional ablation catheter versus conventional ablation catheter alone in the ablation of ventricular premature contractions originating from left ventricular papillary muscle

A prospective, randomized, multicenter study on the safety and efficacy of combined mapping using Advisor HD Grid multipolar catheter and conventional ablation catheter versus conventional ablation catheter alone in the ablation of ventricular premature contractions originating from left ventricular papillary muscle

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088552
Enrollment
Unknown
Registered
2024-08-21
Start date
2024-08-22
Completion date
Unknown
Last updated
2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventricular premature contractions originating from left ventricular papillary muscle

Interventions

Experimental group:Advisor HD Grid catheter was used for mapping and diagnosis, and TCSE catheter was used for radiofrequency ablation.
Control group:Using TCSE catheter alone for mapping and radiofrequency ablation.

Sponsors

Sun Yat sen Memorial Hospital of Sun Yat sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. 18-80 years old; 2.The ECG in lead 12 showed that the patients with monomorphic left ventricular papillary muscle premature contractions, >=8 000 cells/24 h or >= 400 cells/h, were monomorphic early, with different degrees of palpitations, chest tightness and other symptoms. 3. All of them stopped taking anti-arrhythmic drugs for more than 5 half-lives before radiofrequency ablation, and stopped taking amiodarone for more than 4 weeks.

Exclusion criteria

Exclusion criteria: Electrocardiogram, echocardiography, chest X-ray and laboratory tests (myocardial injury markers, electrolytes, etc.) show structural heart disease (such as cardiomyopathy, congenital heart disease, myocarditis, etc.), hereditary arrhythmia syndrome and hyperthyroidism and other systemic diseases.

Design outcomes

Primary

MeasureTime frame
Success rate 12 months after ablation;

Secondary

MeasureTime frame
Immediate success rate of ablation;Single ablation success rate;Mapping time;The earliest excitation time of target potential;Number of ablation points;Ablation time;Fluoroscopy time;Procedural time;

Countries

China

Contacts

Public ContactXie Shuanglun

Sun Yat sen Memorial Hospital of Sun Yat sen University

xieshuanglun@sina.com+86 138 2600 5673

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026