major depressive disorder
Conditions
Interventions
Hypothermia combined with antidepressant treatment group:Hypothermia combined with antidepressant
Normothermic combined with antidepressant treatment group:Normal temperature combined with antidepressant
Healthy control group:None
Sponsors
Zhongda Hospital, School of Medicine, Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients group: ? Hospitalized patients; ? Aged 18-65 years (including 18 and 65 years old), male or female; ? Meet the diagnostic criteria of DSM-5 for depression; ? Patients with depression, 20 <= HAMD-24; ? No history of electroconvulsive therapy; ? Those who have not used psychotropic medication in the past two weeks; ? Those who have not used probiotics in the past one weeks; ? Subjects or their legal guardian sign the informed consent form. Healthy group: ? Select healthy individuals who match the patient group in terms of gender, age, education level, and HAMD-24 rating of<8 points; ? No history of serious heart, brain, or kidney diseases; ? No history of alcohol and drug abuse; ? No family history of mental illness; ? Subjects or their legal guardian sign the informed consent form.
Exclusion criteria
Exclusion criteria: ? History of schizophrenia, alcohol and drug dependence; ? Patients with organic brain diseases and endocrine diseases; ? Patients with severe primary diseases of cardiovascular, liver, and kidney diseases; ? Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores of HAMD-24; | — |
Secondary
| Measure | Time frame |
|---|---|
| MDD related hormone levels;PHQ-9/GAD-7;SERS;Daily monitoring of subjects' body temperature;16S rRNA gene sequencing;CircRNAs specifically expressed in MDD; | — |
Countries
China
Contacts
Public ContactYonggui Yuan
Zhongda Hospital, Affiliated to Southeast University
Outcome results
None listed