The impact of intraoperative blood pressure management guided by TCCD combined with cerebral oxygen saturation monitoring on the incidence of postoperative delirium in elderly patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400088530

Enrollment

Unknown

Registered

2024-08-20

Start date

2024-09-01

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

TCCD Group:During the procedure, blood pressure should be kept within the best average arterial pressure range measured by TCCD.

TCCD+rSO2 Group:During the procedure, keep the blood pressure within the optimal average arterial pressure range based on combined measurements.

rSO2 Group:During the procedure, keep blood pressure within the optimal mean arterial pressure range measured by the brain oxygen monitor.

Control Group:During the procedure, keep the MAP above 65 mmHg.

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: Elderly patients aged 65 to 85 undergoing elective surgery under general anesthesia, classified as ASA I-III.

Exclusion criteria

Exclusion criteria: (1) Heart, vascular, head and neck surgeries; (2) Mini-Mental State Examination (MMSE) score: illiterate = 17 points, primary education = 20 points, secondary education or above = 23 points; (3) BMI 28 kg/m^2; (4) Non-sinus rhythm (such as atrial fibrillation, supraventricular or ventricular premature beats), history of myocardial infarction, history of heart surgery, EF < 50%, NYHA classification = 3, cardiomyopathy, moderate to severe heart valve disease, moderate to severe pulmonary hypertension; (5) History of central nervous system disease or surgery; (6) Carotid artery stenosis; (7) Suffering from mental illness and long-term use of psychiatric medications; (8) Severe liver and kidney dysfunction; (9) Visual, auditory or language communication barriers; (10) Preoperative Hb < 100 g/L; (11) Preoperative albumin < 30 g/L; (12) Alcohol or drug abuse; (13) Planned transfer to ICU after surgery; (14) Unable to provide or refuses to sign informed consent.

Design outcomes

Primary

Measure	Time frame
The incidence of postoperative delirium;	—

Secondary

Measure	Time frame
The severity of postoperative delirium;Duration of postoperative delirium;Liver and kidney function within 3 days after surgery.;Recovery Quality;duration of hospitalization;Incidence of serious cardiovascular complications;	—

Countries

China

Contacts

Public ContactWang Ji

Affliated Hospital of NorthSichuan Medical College

wangjinsmc@sina.com+86 135 6861 2696

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026