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Study on the mechanism of stellate ganglion block inhibiting inflammatory response through TLR4/NF - ? B signaling pathway and improving agitation in children during awakening period

Study on the mechanism of stellate ganglion block inhibiting inflammatory response through TLR4/NF - ? B signaling pathway and improving agitation in children during awakening period

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088527
Enrollment
Unknown
Registered
2024-08-20
Start date
2024-08-23
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

agitation

Interventions

(C) Saline control group (Group C):After general anesthesia, tracheal intubation was performed, followed by stellate ganglion block: 0.9% normal saline 3ml

Sponsors

Guangzhou Women and Children's Medical Center Liuzhou Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1. Aged 36 to 72 months ; 2. Parents agree to participate in this study and sign the informed consent form; 3. ASA physical status I or II; 4. Patients undergoing adenotonsillectomy surgery in otorhinolaryngology.

Exclusion criteria

Exclusion criteria: 1. The parents of the child refused to sign the informed consent form; 2. Two weeks before the surgery, the patient showed symptoms of pneumonia, asthma, bronchitis, or upper respiratory tract infection; 3. The patient has a history of allergies to any medication used in this clinical trial; 4. Children with psychological or neurological disorders, history of using psychotropic or anticonvulsant drugs; 5. Children with developmental delay, attention deficit disorder, and hearing impairment. 6. Infection at the puncture site

Design outcomes

Primary

MeasureTime frame
the incidence of EA;IL; IL-6; IL-1ß; TNF-a;TLR4; NF-?B;

Secondary

MeasureTime frame
FLACC Pain Score;side effect;

Countries

China

Contacts

Public ContactMo Xiaofei

Guangzhou Medical University Affiliated Women and Children's Medical Cente

13560336485@163.com+86 135 6033 6485

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026