Osteoarthritis
Conditions
Interventions
A:two doses of normal saline
B:a single dose of 10 mg dexamethasone before surgery and normal saline after surgery
C:two doses of 5 mg dexamethasone during the perioperative period
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients between the ages of 18 and 75 years with a diagnosis of knee osteoarthritis who were scheduled for elective unilateral primary total knee arthroplasty
Exclusion criteria
Exclusion criteria: 1. History of hormone use within one month before surgery 2. Use of strong opioids within 7 days before surgery 3, the patient has rheumatic immune system diseases (like wind, gout, ankylosing spondylitis, etc.) 4. Patients with liver and kidney failure 5. A history of drug abuse 6. Diabetic patients 7. Patients with gastrointestinal diseases (chronic gastritis, gastric ulcer, etc.) 8. Patients with greater risk of postoperative infection 9. Patients with any history of drug allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidences and severity of PONV within 24 h after surgery;The number and consumption of patients requiring morphine and metoclopramine;AS scores for nausea and vomiting at 2, 4, 6, and 24 h after surgery;Incidences of surgical site infection (SSI) as well as gastrointestinal bleeding (GIB) within 45 days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose levels on days 1, 2, and 3 after operation; | — |
Countries
China
Contacts
Public ContactFu Peiliang
Shanghai Changzheng Hospital
Outcome results
None listed