Expression characteristics of EGR1 in placenta of TPO antibody positive patients and its effect on hypoxic trophoblast cells and its mechanism

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400088511

Enrollment

Unknown

Registered

2024-08-20

Start date

2024-09-01

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thyroid autoimmunity

Interventions

TPO antibody positive group:None

TPO antibody negative group:None

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Aged 20 to 40 years old; (2) Missed abortion occurs at 6-10 weeks of gestation; (3) TPO antibody detection was performed.

Exclusion criteria

Exclusion criteria: (1) Patients with body mass index (BMI) = 30kg/m^2; (2) A history of diabetes or other autoimmune diseases (other than thyroid autoimmune diseases); (3) Uterine malformation; (4) Chromosome karyotype abnormality.

Design outcomes

Primary

Measure	Time frame
EGR1;	—

Secondary

Measure	Time frame
GRP78;PERK;CHOP;	—

Countries

China

Contacts

Public ContactAiping Qin

The First Affiliated Hospital of Guangxi Medical University

1217667556@qq.com+86 139 7710 2456

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026