Postoperative cognitive impairment and perioperative stroke
Conditions
Interventions
Group N:Adjust the infusion rates of propofol and remifentanil during anesthesia induction to reduce mean arterial pressure (MAP) by 25% and 35% of baseline MAP
Group HL:Adjust the infusion rates of propofol and remifentanil during anesthesia induction to reduce mean arterial pressure (MAP) by 25% and 35% of baseline MAP
Group HM:Adjust the infusion rates of propofol and remifentanil during anesthesia induction to reduce mean arterial pressure (MAP) by 25% and 35% of baseline MAP
Group HH:Adjust the infusion rates of propofol and remifentanil during anesthesia induction to reduce mean arterial pressure (MAP) by 25% and 35% of baseline MAP
Sponsors
The First Affiliated Hospital of Wannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18-75 years old 2. Patients undergoing general anesthesia surgery 3. American Society of Anesthesiologists (ASA): ?-? 4. Surgery for patients in supine position
Exclusion criteria
Exclusion criteria: 1.Serious history of heart and cerebrovascular disease (frequent atrial fibrillation or premature ventricular contractions, heart failure, intracranial hypertension, epilepsy, new myocardial infarction and cerebral infarction in the past six months, etc.) 2.Pulmonary diseases and severe liver and kidney diseases (such as chronic obstructive pulmonary disease, uremia, cirrhosis, etc.) 3.Patients who require heart, lung, and cerebrovascular related surgeries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean blood flow velocity of middle cerebral artery,Vm;Cerebral oxygen saturation,rSO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, MAP; | — |
Countries
China
Contacts
Public ContactWenjun Guo
The First Affiliated Hospital of Wannan Medical College
Outcome results
None listed