Skip to content

Prophylactic management strategies for severe oral mucositis based on oral PH in patients treated with radiotherapy for nasopharyngeal carcinoma - a multicenter randomized controlled study

Prophylactic management strategies for severe oral mucositis based on oral PH in patients treated with radiotherapy for nasopharyngeal carcinoma - a multicenter randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088500
Enrollment
Unknown
Registered
2024-08-20
Start date
2024-08-31
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasopharyngeal carcinoma

Interventions

Intervention group:On the basis of the routine oral care program, the prevention and management strategy of severe oral mucositis based on oral PH value is used to intervene, and the specific interven
Prepare the precision PH test strips, various mouthwashes and other items needed to monitor the PH value of the mouth
(2) Provide unified training for the medical staff participating in the study to ensure that they are proficient in the program content and operation process. (2) Plan: (1) Specify the specific evalua
? Develop a detailed personalized oral care plan and adjust it in time according to PH value changes
? Plan the time arrangement and specific content of health education, including lectures, publicity materials, etc.
? Determine the process and communication methods for collaboration with other departments. (3) Implementation 1) Before radiotherapy: (1) Conduct a comprehensive oral examination for the patient and
(2) Conduct health education for patients, explain oral problems that may occur during radiotherapy and how to deal with them, and emphasize the importance of maintaining oral cleanliness and stable P
? According to the specific situation of patients, develop personalized oral care plan
(4) Prepare the daily oral care diary for patients, urge patients to complete oral self-care and supervise patients t

Sponsors

Affiliated Cancer Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Patients with newly diagnosed and untreated nasopharyngeal carcinoma; (2) between the ages of 18 and 75; (3) There is no prior or concurrent malignant tumor; (4) Expected survival of at least 6 months.

Exclusion criteria

Exclusion criteria: (1) Oral mucositis existed before the test; (2) Suffering from serious diseases of the heart, lung, liver, kidney and other organs; (3) Pregnant and lactating women; (4) Patients allergic to this test mouthwash; (5) Patients with a history of mental illness or mental disorders.

Design outcomes

Primary

MeasureTime frame
Incidence and severity of grade I-IV oral mucositis;

Secondary

MeasureTime frame
Oral PH;xerostomia;

Countries

China

Contacts

Public ContactLi Dan

Affiliated Cancer Hospital of Fudan University

361847778@qq.com+86 180 1731 7399

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026