gastroesophageal refractory reflux disease
Conditions
Interventions
Endoscopic cardioconstriction (ECCL) group:Patients with GERD were treated with endoscopic cardioconstriction.
Radiofrequency ablation (ERFA) group:GERD patients were treated with ERFA.
Sponsors
Shenzhen Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1)18-80 years old; (2) The course of disease =6 months, with typical acid reflux, heartburn and other symptoms, the diagnosis of GERD patients; (3) GERD patients who took double doses of acid suppressive drugs for 8 weeks without relief of symptoms; (4) Agree to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Endoscopic examination reveals esophageal early cancer, >3cm Barrett's esophagus and other precancerous lesions, and advanced-stage cancer of the upper gastrointestinal tract; (2) Patients with a >2cm hiatal hernia, severe reflux esophagitis (LA-C, LA-D grade), combined with esophagogastric varices, esophageal ulcer or stricture, and patients who have had previous gastroesophageal surgery; (3) Patients with achalasia, diffuse esophageal spasm and other esophageal motility disorders, systemic sclerosis, Sjogren's syndrome and other rheumatological and immunological diseases, and eosinophilic esophagitis; (4) Patients with a history of endoscopic or surgical anti-reflux procedures; (5) Patients with coagulation disorders, severe cardiopulmonary diseases, and those who cannot tolerate anesthesia, endoscopy, and treatment; (6) Postpartum women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroesophageal reflux disease questionnaire (GERD-Q) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endoscopic LA grading;Endoscopic Hill grading; | — |
Countries
China
Contacts
Public ContactYing Zhu
Shenzhen Hospital of Southern Medical University
Outcome results
None listed