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Analyzing the Correlation between ALDH2 Gene Polymorphism and Postoperative Pain after Thoracoscopic Lobectomy Based on Pain Trajectory

Analyzing the Correlation between ALDH2 Gene Polymorphism and Postoperative Pain after Thoracoscopic Lobectomy Based on Pain Trajectory

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400088443
Enrollment
Unknown
Registered
2024-08-19
Start date
2024-08-19
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Interventions

Grouping Based on Postoperative Pain Trajectory:Finally divided into mild pain group, moderate pain group, and severe pain group

Sponsors

Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients undergoing scheduled thoracoscopic lobectomy; 2. Age=18.

Exclusion criteria

Exclusion criteria: 1. Patients who are not scheduled to undergo a second operation within 7 days after surgery; 2. Patients who were transferred to thoracotomy during operation; 3. Patients with mental illness or psychological disorder who are unable to respond to the questionnaire; 4. Patients who have chest surgery history before the study; 5. Patients with an incomplete collected data or refused to participate in the study.

Design outcomes

Primary

MeasureTime frame
Relationship between ALDH2 gene polymorphism and pain after thoracoscopic lobectomy;—

Secondary

MeasureTime frame
The ALDH2 Genotype of Subjects;Pain Trajectory;The Level of 4-HNE in Serum;Operation Duration;Number of Holes in the Endoscope;Single Lung Ventilation Duration;Anesthesia Duration;Intubation Mode;Number of Thick Drainage Tubes;Length of Insertion of Thick Drainage Tubes;Number of Thin Drainage Tubes;Length of Insertion of Thin Drainage Tubes;Duration of Deep Venous Tube Insertion;Postoperative Nausea and Vomiting Score;Postoperative Radiotherapy or Chemotherapy;Postoperative Complication Clavein Classification;Anesthesia Mode;Preoperative Charlson Comorbidity Index;Preoperative Numerical Rating Scale;Brief Measure of Emotional Preoperative Stress(B-MEPS) Scale;First time of early ambulation;Alcohol Test Result;Alcohol and Blush questionnaire;Smoking Index;Alcohol Drunk History;Quality of Recovery Score;Perioperative Analgesic Dosage;—

Countries

China

Contacts

Public ContactYun Wu

Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University

wuyunanyi@163.com+86 138 6595 8254

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026