Sedation before surgery
Conditions
Interventions
Experimental group 1 ( R1 group ):The loading dose of remazolam was 0.2 mg/kg, and the injection time was 30 s.
Experimental group2 ( R2 group ):The loading dose of remazolam was 0.3 mg/kg, and the injection time was 30 s.
Experimental group3 ( R3 group ):The loading dose of remazolam was 0.4 mg/kg, and the injection time was 30 s.
Experimental group4 ( R4 group ):The loading dose of remazolam was 0.5 mg/kg, and the injection time was 30 s.
Experimental group5 ( R5 group ):The loading dose of remazolam was 0.6 mg/kg, and the injection time was 30 s.
Sponsors
Shaoxing Shangyu Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ( 1 ) American Society of Anesthesiologists ( ASA ) grade I-II ; ( 2 ) Aged 18 to 65 years, scheduled for elective non-cardiac surgery ; ( 3 ) Body mass index ( BMI ) was 18-28kg/m^2 ; ( 4 ) According to the provisions of the GCP, to obtain informed consent, volunteer to participate.
Exclusion criteria
Exclusion criteria: ( 1 ) Drug resistance to benzodiazepines or other anesthetics ; ( 2 ) Allergic or suspicious allergies to the drugs used in the study ; ( 3 ) Frequent use of antipsychotics or antidepressants, alcohol or drug dependence ; ( 4 ) BIS 2, with the possibility of respiratory tract management difficulties ; ( 6 ) History of obstructive sleep apnea syndrome ; ( 7 ) History of bronchiectasis and asthma ; ( 8 ) Arrhythmia ; ( 9 ) Neuromuscular diseases ; ( 10 ) Anesthesiologists considered it inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BIS values; | — |
Secondary
| Measure | Time frame |
|---|---|
| SBP, Systolic Blood Pressure;DBP, diastolic blood pressure;HR, heart rate;SPO2; | — |
Countries
China
Contacts
Public ContactChen Jianxiao
35 Banshan Road, Baiguan Street, Shangyu District, Shaoxing, Zhejiang, China
Outcome results
None listed