Pain
Conditions
Interventions
Bupivacaine liposome group(PAI-L):Periarticular injection with the regimen "Bupivacaine liposome 266 mg + saline, total volume 50 ml".
Ropivacaine group (PAI-R):Periarticular injection with the regimen "Ropivacaine 150mg + Morphine 10mg + Methylprednisolone 40mg + Saline, total volume 50ml".
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Patients undergoing unilateral UKA for the first time; 2) Aged 18 years or older; 3) ASA class I-III; 4) Informed about the clinical trial and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Pregnant patients; 2) History of allergy to amide-type local anaesthetics, or allergy to liposomal bupivacaine; 3) Combination of severe hepatic, renal, and cardiac insufficiency; 4) Combination of comorbidities that may affect postoperative recovery, such as sequelae of cerebral infarction, Parkinson's disease, and Alzheimer's disease, etc. 5) Previous history of narcotic dependence and drug abuse; 6) Combination of psychiatric disorders; 7) Currently on hormone use; 8) Preoperative electrocardiograms suggesting that the heart rate is <50 beats, or there is a prolonged QT interval, or pre-excitation syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| knee mobility;Time to first active straight leg raise, time to get out of bed;Patient satisfaction;Dosage of postoperative analgesic drugs; | — |
Countries
China
Contacts
Public ContactChen Feng
Shanghai General Hospital
Outcome results
None listed