Postoperative delirium
Conditions
Interventions
Remimazolam tosylate group (group R):Remimazolam tosylate is induced at 0.2-0.3 mg/kg and maintained at 0.5-1.2 mg/(kg·h).
Propofol group (group P):Propofol is induced at 1.0-1.5 mg/kg and maintained at 2-10 mg/(kg·h).
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Urological surgery under general anesthesia 2. Age 65 years old and above 3. ASA grading I-III 4. Body mass index (BMI) 18-28 kg/m2
Exclusion criteria
Exclusion criteria: 1. Emergency surgery 2. Those who are unable to communicate in speech due to deafness or muteness 3. Central nervous system disease (cerebral hemorrhage, cerebral infarction) or psychiatric disease, preoperative dementia, memory or cognitive dysfunction 4. Other conditions, including intolerance or allergy to benzodiazepines, long-term preoperative use of benzodiazepines or opioid analgesics, myasthenia gravis, schizophrenia and severe depressive state, preoperative sleep disturbance 5. Severe cardiopulmonary disease (including moderate to severe valvular heart disease, second- or third-degree atrioventricular block, moderate to severe decline in lung function) 6. The duration of the operation= 4 hours or the duration of the operation<1 hour 7. Intraoperative blood loss= 600ml or hemoglobin <80g/L 8. Those who are admitted to the recovery room after surgery and do not plan to be intubated again 9. Admission to ICU after surgery 10. During the course of the study, the trial needs to be terminated due to serious adverse reactions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time from the end of the operation to extubation;Intraoperative hemodynamic changes;QoR-15 score within 24 hours after surgery;Hemoglobin concentration at suture;Perioperative propofol/remimazolam tosylate, remifentanil consumption;Intraoperative vasoactive drug use;Intraoperative fluid volume;Intraoperative fluid output;Consumption of salvage analgesic drugs within 24 postoperative periods;Length of hospital stay after surgery;Adverse reaction rate; | — |
Countries
China
Contacts
Public ContactGuanglei Wang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed