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Effect of prophylactic infusion of norepinephrine on postoperative gastrointestinal function in elderly patients undergoing intestinal surgery: a randomized trial

Effect of prophylactic infusion of norepinephrine on postoperative gastrointestinal function in elderly patients undergoing intestinal surgery: a randomized trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088380
Enrollment
Unknown
Registered
2024-08-16
Start date
2024-08-16
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal function after intestinal surgery

Interventions

Norepinephrine group:The initial dose of norepinephrine was 0.01µg·kg-1·min-1, and the initial dose was 0.01~0.1 µg·kg-1·min-1 until the end of the operation.
Normal saline group:The same regimen gives the same amount of saline.

Sponsors

Subei People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) Definite diagnosis and complete preoperative examination; (2) Signing informed consent; (3) Patients who plan to undergo endoscopic intestinal surgery under general anesthesia; (4) Age 60-85 years old; (5) American Association of Anesthesiologists (ASA) classification: Grade I-III

Exclusion criteria

Exclusion criteria: (1) complicated with severe hypertension, heart disease, arrhythmia; (2) illiterate people with communication difficulties and preoperative dementia; (3) Have mental and psychological diseases in the past, long-term use of sedative anti-depressant anti-anxiety drugs. (4) Recent history of gastrointestinal surgery.

Design outcomes

Primary

MeasureTime frame
Patient's self-reported time of first exhaust;

Secondary

MeasureTime frame
Postoperative gastrointestinal function score (I-FEED);Time of first defecation;Time of first oral feeding;Incidence of delirium;Postoperative pain score;Sleep quality;Postoperative nausea and vomiting (PONV);Hospitalization costs and length of stay;

Countries

China

Contacts

Public ContactCunjin Wang

Subei People's Hospital

zebra1987@126.com+86 180 5106 1453

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026