acute pain
Conditions
Interventions
experimental group:Hydromorphone hydrochloride injection
Sponsors
the Third People's Hospital of Chengdu
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1)patients with acute moderate to severe pain (NRS = 4) requiring opioid analgesic treatment; 2) adult patients (aged = 18 years); 3)obtained informed consent from the patient.
Exclusion criteria
Exclusion criteria: 1) pregnant or lactating women; 2) allergic to opioids including hydromorphone or butorphanol; 3) chronic use of opioids or a history of opioid addiction; 4) presence of medical conditions that may affect the metabolism of opioid analgesics (severe hepatic or renal insufficiency); 5) systolic blood pressure less than 90 mmHg, heart rate less than 50 beats/min, or oxygen saturation less than 90% on room air; 6) intoxication by alcohol or other drugs; 7) presence of symptoms of respiratory depression, suffering from acute or severe bronchial asthma; 8) presence or risk of progression to gastrointestinal obstruction, especially paralytic intestinal obstruction; 9) loss of hearing or vision, or any other condition that may substantially interfere with the collection of data for the study; 10) communication deficits (e.g. psychiatric or neurological disorders or sedation); 11) use of opioids within the previous 24 hours; 12) any medication that might interact with one of the study medications; 13) had participated in this study or concurrently participated in any clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain relief rate;Time to achieve analgesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions;pain locations;The proportion of target analgesia score achieved at each time point;Additional analgesics and dosage;Total analgesic dose;Length of stay in the emergency department;the blood pressure, heart rate, respiratory rate , and pulse oxygen saturation ; | — |
Countries
China
Contacts
Public ContactXiang Tao
the Third People's Hospital of Chengdu
Outcome results
None listed