Full-thickness skin defect wounds
Conditions
Interventions
Test group:aFGF+AD implantation is performed to observe the wound, and thin STSG grafting is performed once AD is fully vascularized.
Control group:Solvent+AD implantation is performed to observe the wound, and thin STSG grafting is performed once AD is fully vascularized.
Sponsors
Central Hospital Affiliated to Shandong First Medical University (Jinan Central Hospital)
Eligibility
Sex/Gender
All
Age
3 Years to 65 Years
Inclusion criteria
Inclusion criteria: Those who meet the following four criteria are included: 3 years old = age =65 years old; relatively flat full-thickness skin defect wound with well-vascularized wound base and edge tissue; wound located in the limbs or trunk, and the wound with an area =36cm^2 and the width was =4cm; Patients and/or their guardians understood and signed the informed consent form.
Exclusion criteria
Exclusion criteria: The exclusion criteria include: Extensive deep burn with open wound more than 10% total body surface area (TBSA) or severe systemic condition; Malnutrition, plasma albumin < 30 g/L, or hemoglobin < 9 g/L; Wounds with local infection, more necrotic tissue, poor blood supply to the wound base, sinus tract, or tendon or bone exposure; Radiation ulcer wound; Pressure ulcer or diabetic ulcer with transcutaneous oxygen pressure of skin around the wound less than 40 mmHg; Allergic to collagen or chondroitin sulfate, or allergic diseases; Pregnant or lactating women; Those requiring ongoing treatment with oral corticosteroids; Patients with poorly controlled diabetes or severe cardiovascular, hepatic, renal or hematological diseases; People with mental disorders or epilepsy; Any condition considered by the investigator to be likely to increase the risk to the subject or affect the evaluation of efficacy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grafting interval time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival quality of skin graft;Survival rate of skin graft;Wound healing time of recipient site;Rate of healing wound contraction;Modified Vancouver Scar Scale score; | — |
Countries
China
Contacts
Public ContactGuodong Song
Central Hospital Affiliated to Shandong First Medical University (Jinan Central Hospital)
Outcome results
None listed