Maternal Hypothyroxinemia
Conditions
Interventions
intervention group:LT4 administration
Iodine iron supplement group:Iodine, iron supplement
Control group:none
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
19 Years to 40 Years
Inclusion criteria
Inclusion criteria: Research Proposal (I):1. Women of reproductive age (19-40 years old); 2. Volunteer to participate in the study. Research Proposal (II~III):1.Woman in preconception period. Research Proposal (IV):1.Women who are at high risk of Hypothyroxinemia during pregnancy preparation screened by the risk prediction model of low thyroid hormone Research Proposal (V):1.Pregnant women with confirmed hypothyroxinemia
Exclusion criteria
Exclusion criteria: Research Proposal (I):1.Patients with positive thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb);2.Patients with a personal or family history of thyroid disease;3.Patients with visible or palpable goiter;4.Patients taking estrogen medications. Research Proposal (II~V):1. Personal history of previous thyroid disease;2. Taking drugs that affect thyroid function before pregnancy;3. Physical examination showed goiter;4. Autoimmune diseases, such as systemic lupus erythematosus, connective tissue disease, anticardiolipin syndrome, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Offspring neurodevelopment;premature delivery;Serum FT4 and TSH levels;Cost-Effectiveness Ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Macrosomia;Hypertensive disorders of pregnancy;Gestational diabetes mellitus; | — |
Countries
China
Contacts
Public ContactQiaoling Du
Shanghai First Maternity and Infant Hospital
Outcome results
None listed