None listed
Conditions
Interventions
Remimazolam group:During anesthesia induction, 0.2 mg/kg remimazolam was injected intravenously, followed by a constant intravenous pump at 0.5 mg/kg/h. During anesthesia maintenance, remazolam doses
Propofol group:During anesthesia induction, plasma target controlled infusion of propofol was 3µg/ml, and during anesthesia maintenance, the dose of propofol was maintained at 2-3µg/ml.
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients scheduled for elective surgery at the Day Surgery Center of the First Affiliated Hospital of Guangxi Medical University from December 2021 to September 2022, with scheduled surgical duration of less than 2 hours, aged 18 to 65 years, ASA grade I to II, BMI 18 to 25 kg/m2, and Mallampati grade I to III were included
Exclusion criteria
Exclusion criteria: (1) Patients with other severe complications such as diabetes, severe obesity, chronic obstructive pulmonary disease, asthma, severe hypertension, etc.; (2) Mental disorders; (3) Hematological disorders such as anemia, thrombocytopenia, leukemia, etc.; (4) Hepatic dysfunction; (5) Substance abuse; (6) Alcoholism or allergy to drugs, especially to propofol and benzodiazepines; (7) Pregnant or lactating women; (8) Participation in any other drug clinical trials within the past 3 months; (9) Baseline blood pressure: systolic pressure 180 mmHg, diastolic pressure 100 mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy;Safety; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP);Heart rate (HR);the time to loss of consciousness (LOC);Incidence of injection pain;Number of patients requiring vasopressor support to maintain circulation during surgery;Time from cessation of medication to eye opening;Time from cessation of medication to extubation;PACU stay duration;Time to achieve MOAA/S score > 4 after cessation of medication;Visual Analog Scale (VAS) scores 30 minutes post-extubation;Occurrence of adverse reactions in patients during follow-up on the first and seventh postoperative days; | — |
Countries
China
Contacts
Public ContactYunan Lin
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed