Clinical value of TAT, t-PAIC, TM and PIC in septic coagulopathy

Clinical value of TAT, t-PAIC, TM and PIC in DIC induced by sepsis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400088284

Enrollment

Unknown

Registered

2024-08-15

Start date

2024-09-01

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis induced coagulopathy

Interventions

group of sepsis induced coagulopathy:None

group of no-sepsis induced coagulopathy:None

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria of Sepsis 3.0 (infection + SOFA score >= 2), (2) Obtain informed consent from patients or their family members, (3) Aged 18 to 85 years (inclusive), regardless of sex.

Exclusion criteria

Exclusion criteria: (1) Decompensated liver cirrhosis (Child-Pugh grade B or C); (2) Hematological disorders; (3) Thrombolytic or anticoagulant drugs (such as thrombolysis or hemodialysis) before entering the group; (4) Active tumors; (5) Patients in pregnancy or lactation.

Design outcomes

Primary

Measure	Time frame
Thrombin–antithrombin complex, TAT;thrombomodulin, TM;a2-Plasmin inhibitor-Plasmin complex, PIC;tissue plasminogen activation inhibition complex, t-PAIC;Syndecan-1;	—

Countries

China

Contacts

Public ContactWang Tao

Binzhou Medical University Hospital

wtsjr@163.com+86 159 5436 8203

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026