Effect of probiotics on bone mineral density and skeletal muscle mass in adults with low bone mass

Effect of lactobacillus on bone mineral density and skeletal muscle mass in adults with low bone mass

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400088274

Enrollment

Unknown

Registered

2024-08-14

Start date

2024-01-05

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low bone mineral density

Interventions

Control group:NA

Lactobacillus Fermentum F6 group :Lactobacillus fermentum F6 was presented as a solid drink, with each bag containing =1X10^10 CFU of probiotics, twice daily for 1 year.

Lactobacillus plantarum PL152 group:Lactobacillus plantarum PL152 was presented as a solid drink, with each bag containing =1X10^10 CFU of probiotics, twice daily for 1 year.

Bifidobacterium lactis BAPerfectus006 group:Bifidobacterium lactis BAPerfectus006 was presented as a solid drink, with each bag containing =1X10^10 CFU of probiotics, twice daily for 1 year.

Eligibility

Sex/Gender

All

Age

30 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Guangdong residents (duration >5 years). 2. Age =30 years old, Han. 3. Adults with low bone mineral density detected by dual energy X-ray absorptiometry (DXA). 4. Voluntary consent and signed informed consent. 5. Mental and cognitive normal, able to correctly understand the meaning of each item of the questionnaires.

Exclusion criteria

Exclusion criteria: 1. Pregnancy, lactation, planning pregnancy 2. People with the following diseases: Inflammatory bowel disease (ulcerative colitis, Crohn's disease, uncertain colitis, etc.), moderate to severe irritable bowel syndrome, infectious, ulcerative gastroenteritis, nutrient malabsorption or malabsorption (such as celiac disease, steatosis, etc.), major gastrointestinal surgery (in addition to cholecystectomy and appendectomy), severe kidney disease, severe liver disease, severe diabetes, Malignant tumors, neuropsychiatric diseases (such as depression and long-term medication), parathyroid diseases, etc.. 3. Long-term use of drugs that affect gastrointestinal tract or bone mineral metabolism (such as antibiotics, estrogens, etc.). 4. Long-term use of dietary supplement products (such as probiotics, dietary fiber, vitamins, calcium tablets, etc.) .

Design outcomes

Primary

Measure	Time frame
Bone mineral density;Skeletal muscle mass;	—

Secondary

Measure	Time frame
Gut microbiota;Serum biomarkers;	—

Countries

China

Contacts

Public ContactXiao Sumei

Sun Yat-Sen University

xiaosm3@mail.sysu.edu.cn+86 20 8733 0151

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026