Gastro-oesophageal reflux disease
Conditions
Interventions
Standard dose group:Tegoprazan 50mg/day
RE grade A~B, oral administration for 4 weeks
RE grade C~D, oral administration for 8 weeks
Low-dose group:Tegoprazan 50mg, once every other day, RE grade A~B, oral administration for 4 weeks
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: GERD is defined as having heartburn symptoms 1 time per week, endoscopic diagnosis of reflux esophagitis grade A~D, age 18~65 years.
Exclusion criteria
Exclusion criteria: hiatal hernia, Barrett's esophagus; peptic ulcer; various malignant tumors; heart, liver, kidney, pulmonary insufficiency; pregnancy,in perinatal and lactating women; patients with chronic diseases such as endocrine and metabolic diseases and psychiatric diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healing rate of esophageal mucosal lesions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrin-17;Pepsinogen;Pepsin;Pancreatic Exocrine Function;Small Intestinal Bacterial Overgrowth; | — |
Countries
China
Contacts
Public ContactZhiyin Huang
Department of Gastroenterology and Hematology, West China Hospital, Sichuan University
Outcome results
None listed