sepsis
Conditions
Interventions
Healthy Control Group:None
Sepsis induced Myocardial Dysfunction Group:None
Sepsis non cardiac dysfunction group:None
Sponsors
The Second Hospital & Clinical Medical School, Lanzhou University
Eligibility
Sex/Gender
All
Age
14 Years to 100 Years
Inclusion criteria
Inclusion criteria: Sepsis patients (aged = 14 years) who meet the criteria of Sepsis 3.0 in the Intensive Care Medicine Department of Lanzhou University Second Hospital.
Exclusion criteria
Exclusion criteria: 1) Individuals with acute myocardial infarction, cardiac surgery, or heart function grade IV within the past month; 2) End stage renal disease requiring renal replacement therapy; 3) Patients with severe liver dysfunction (Child Pugh C grade or above), 4) Individuals with severe neurological disorders (such as Parkinson's disease, Alzheimer's disease); 5) Individuals who have undergone major surgery or severe trauma within the past month prior to enrollment; 6) Diagnosed with sepsis for more than 24 hours or those who have undergone blood purification or ECMO treatment before enrollment (excluding those who require in vitro support due to the condition after sample retention); 7) Individuals with active tumors or autoimmune diseases (such as those receiving radiation therapy, chemotherapy, long-term or extensive hormone therapy); 8) Within one month before enrollment, take antioxidants such as vitamin C, vitamin E, coenzyme Q10, glutathione, or trimetazidine, which interfere with the results of metabolomics analysis (excluding those who use the above drugs due to illness needs after sample retention); 9) Pregnant or lactating women; 10) Those who refuse to participate in this study and have incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomics;H2O2;MDA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in mitochondrial RET related markers during ICU transfer with improvement; | — |
Countries
CHINA
Contacts
Public ContactNannan He
The Second Hospital & Clinical Medical School, Lanzhou University
Outcome results
None listed