HIV/AIDS
Conditions
Interventions
The traditional HIV hypoviremia management model group:According to the patients condition, researchers can choose their own dual or triple antiretroviral therapy without ABT until 24 weeks.
A new model group for optimized management of hypoviremia:ABT+ original ART scheme /OBR, until 24 weeks
Sponsors
Zhengzhou Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Over 18 years old (including the critical value), both Chinese male and female; 2) Diagnosed with HIV/AIDS and received antiviral treatment for more than 24 weeks;; 3) The last virological test before screening (within 6 months) was 50 copies /mL= plasma HIV-1 RNA < 1000 copies /mL, and the time before screening was at least 2 weeks from the screening retest date, and the virological test was maintained at 50 copies /mL= plasma HIV-1 RNA < 1000 copies/ml;. 4) Sign the informed consent of the patient voluntarily, and ensure the follow-up; 5) Unplanned relocation from the current test site during the course of the test.
Exclusion criteria
Exclusion criteria: 1) Use of Fusion inhibitors targeting gp41 within the previous 3 months; 2) Active opportunistic infection or AIDS-related malignancy (as stipulated in the national AIDS Treatment guidelines); Patients who had an opportunistic infection in the 6 months prior to enrollment, but whose disease was considered stable by investigators for less than 14 days; Any liver disease caused by vascular, metabolic, autoimmune or tumor; 3) Severe cardiovascular disease, cancer, acute severe infection, kidney injury, and other diseases that the researchers determined could not be included; 4) Known resistance to the investigational drug or allergy to the active ingredient or any additive of the investigational drug; 5) The following results were detected during the screening period: hemoglobin 1.5 times the upper limit of normal level, aspartate aminotransferase/alanine aminotransferase/alkaline phosphatase >3 times the upper limit of normal level, and total bilirubin >2 times the upper limit of normal level; 6) Pregnant and lactating women; 7) Those who have family planning; 8) Gowster; 9) Patients with serious mental and neurological diseases; 10) Those who have a history of alcoholism and cannot stop; 11) severe gastrointestinal ulcer; 12) Acute hepatitis; Acute and chronic pancreatitis; 13) Situations in which other researchers consider it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HIV-1 RNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD4+T lymphocyte count;Life quality score;New incidence of AIDS-related diseases;CD8+T lymphocyte count;The ratio of CD4+/CD8+T;AIDS-related medical expenses; | — |
Countries
China
Contacts
Public ContactXuan Yang
Zhengzhou Sixth People's Hospital
Outcome results
None listed