Acute Kidney Injury
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine 0.4µg/kg was infused for 10 min before induction of anesthesia, and 0.4 ug/kg/h was infused continuously during the operation, until half an hour before the end o
Control group:The same amount of normal saline was infused over a period of 10 minutes prior to anesthesia induction, and an equivalent volume of normal saline was continuously administered throughout
Sponsors
Department of Anesthesiology, the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients aged >=65 years, scheduled for lower extremity orthopedic surgery under general anesthesia, with an expected surgical duration of >1 hour.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Those who have not been well controlled by hypertension level 3; 3. Sick sinus syndrome, conduction block or sinus bradynasty (heart rate < 60 beats/min); 4. Severe anemia (hemoglobin < 7.0 g/dl); 5. Systemic infection before surgery; 6. Preoperative liver disease (Child-Pugh grade C); 7. Patients on dialysis with preoperative renal failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence rate of postoperative acute kidney injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| eGFR on the first, second and third days after surgery;Cystatin C on the first, second and third days after surgery;The incidence of delirium during hospitalization;The proportion of patients admitted to the ICU;The incidence of nausea and vomiting during hospitalization;Mortality during hospitalization;Length of hospital stay;The incidence of pneumonia during hospitalization;The incidence of stroke during hospitalization; | — |
Countries
China
Contacts
Public ContactFuhai Ji
The First Affiliated Hospital of Suzhou University
Outcome results
None listed