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Novel approaches to the management of recurrent pregnancy loss: The OPTIMUM (OPtimization of Thyroid function, Thrombophilia, Immunity, and Uterine Milieu) treatment strategy:a prospective cohort study

Novel approaches to the management of recurrent pregnancy loss: The OPTIMUM (Optimization of Thyroid function, Thrombophilia, Immunity, and Uterine Milieu) treatment strategy:a prospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088218
Enrollment
Unknown
Registered
2024-08-13
Start date
2024-09-01
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

recurrent pregnancy loss

Interventions

Optimization of treatment group (optimize treatment):None
Untreated group (no optimize treatment):None

Sponsors

Second Hospital of Lanzhou University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Two or more consecutive pregnancy losses; Both parents have normal chromosome karyotypes; Age greater than 18 years less than 40 years; Normal menstrual cycle and basic sex hormones; Normal routine semen examination of the male partner and exclusion of a history of genetic disorders in both spouses.

Exclusion criteria

Exclusion criteria: Malformations of the reproductive tract (unicornuate uterus, bicornuate uterus, complete uterine septum); Assisted reproductive conception; Chromosomal abnormalities in both spouses; Inability to receive follow-up visits.

Design outcomes

Primary

MeasureTime frame
Gestational outcome after a second pregnancy;

Secondary

MeasureTime frame
Best optimized post-treatment cost-effectiveness analysis;Neonatal outcomes in the live birth group;

Countries

China

Contacts

Public ContactWang Fang

The second hospital of Lanzhou University

ery_fwang@lzu.edu.cn+86 139 1930 2888

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026