Intracranial artery stenosis Progressive ischemic stroke Emergency angioplasty
Conditions
Interventions
The control group:standard medical management
The experimental group:emergency angioplasty
Sponsors
Shenzhen Hospital of Southern Medical Unversity
Eligibility
Sex/Gender
All
Age
18 Years to 110 Years
Inclusion criteria
Inclusion criteria: 1.Age>= 18 years old; 2.Stroke onset within 14 days; 3.Pre-onset mRS =2 a and an increase in NIHSS >=4 at progression; 5.ASPECTS or pc-ASPECTS >= 6; 6.Imaging demonstrates watershed cerebral infarction or hypoperfusion in the culprit vascular territory; 7.Progressive ischemic stroke caused by severe stenosis (70%-99%, measured according to the WASID criteria) of intracranial large vessels, screened by CTA/MRA and confirmed by DSA, including the intracranial internal carotid artery (C4-C7 segments), the middle cerebral artery (M1 and M2 segments), basilar artery, and V4 segment of the vertebral artery; 8.The patient or the agent signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Diameter of target vessel 185 mmHg or diastolic BP >110 mmHg); 21.Life expectancy <3 months (e.g., terminal illnesses such as malignancy, severe cardiopulmonary disease). 1.Other conditions deemed unsuitable for participation by the investigator (e.g., inability to understand/comply with study procedures/follow-up due to psychiatric disorders, cognitive or emotional impairments).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The modified Rankin Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of symptomatic intracranial hemorrhage;NIHSS score;EQ-5D-5L;Incidence of symptomatic intracranial hemorrhage; | — |
Countries
China
Contacts
Public ContactHe XiongJun
Shenzhen Hospital of Southern Medical Unversity
Outcome results
None listed