allergic rhinitis
Conditions
Interventions
Treatment group:Pterygopalatine ganglion block: 0.75% bupivacaine injection 1 ml + dexamethasone sodium phosphate injection 0.5 ml + physiological saline 1.5 ml
Control group:Pterygopalatine ganglion block drug: 0.75% bupivacaine injection 1ml + saline 2ml
Sponsors
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Diagnosed with allergic rhinitis/allergic rhinitis according to the Chinese Guidelines for the Diagnosis and Treatment of Allergic Rhinitis1. Those with major symptoms (nasal congestion, runny nose, sneezing and nasal itching) having episodes more than 4 days per week and symptoms lasting more than 4 weeks; (2) Those who have had poor results from glucocorticosteroids, antihistamines or immunotherapy; (3) A mean total nasal symptom score of =4 in the 1 week prior to treatment; (4) Aged between 18 and 60 years (including 18 and 60 years); (5) Those who can correctly describe their wishes, voluntarily fill in the informed consent form and agree to participate in the clinical trial.
Exclusion criteria
Exclusion criteria: (1) Patients with organic nasal diseases such as nasal polyps, sinusitis, and obvious deviated nasal septum; and (2) Patients with episodic respiratory diseases such as asthma; (3) Patients who have undergone surgical treatment such as pterygoid nerve, Iwata nerve severance or turbinoplasty; (4) Pregnant or breastfeeding women who are preparing to become pregnant while receiving treatment; (5) Psychiatric patients who are unable to cooperate with the treatment and follow-up; (6) Patients with bleeding tendency, coagulation disorders, and diabetes mellitus;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective rate of improvement of nasal symptoms;Drug injection complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nasal symptoms (stuffy nose, runny nose, sneezing, itchy nose) VAS;Rhino-conjunctivitis quality of life questionnaire,RQLQ;Total nasal respiratory volume, TNRV;Total nasal volume,TNV;Total nasal resistance, TNR; | — |
Countries
China
Contacts
Public ContactLijuan Lu
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed