Metabolic Syndrome
Conditions
Interventions
Interventions:Subjects are instructed to take one capsule of probiotics daily for a total of 12 weeks
Placebo Control:Subjects are instructed to take one capsule of placebo daily for a total of 12 weeks
Sponsors
Department of Nutrition, School of Public Health, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Local residents aged between 40-65 years old; • Central obesity defined as waist circumference =90 cm in males or =80 cm in females, Plus any two of the following four conditions i) Elevated triglycerides: serum triglycerides =150 mg/dL (1.7 mmol/L); ii) Reduced HDL cholesterol: serum HDL-c <40 mg/dL (1.03 mmol/L) in males or <50 mg/dL (1.29 mmol/L) in females; iii) Elevated blood pressure: systolic blood pressure =130 mmHg or diastolic blood pressure =85 mmHg; iv) Elevated fasting plasma glucose: fasting plasma glucose =100 mg/dL (5.6 mmol/L) 2. Irregular habit of taking probiotic containing products; Or those who have taken it in the past but have stopped for more than one month; 3. Informed consent and voluntary participation in the experiment.
Exclusion criteria
Exclusion criteria: • Acute illness or current evidence of acute or chronic inflammatory of infective diseases; • Presence of any systemic, cardiovascular diseases as well as severe hepatic and renal impairment, other endocrine disorders such as abnormal thyroid function, and tumours; • Presence of any psychotropic drugs or medication which might interfere with metabolic homoeostasis and gut microbiota, especially antibiotics and probiotics 4 weeks before recruitment • Women who were pregnant or intended to be pregnant during the study. • Allergy or hypersensitivity to the samples under test. • Mental illness rendering them unable to understand the nature, scope, and possible consequences of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiometabolic risk factors; | — |
Secondary
| Measure | Time frame |
|---|---|
| gut microbiota;Gastrointestinal comfort;Sleep quality;Mental health;Liver function;Kidney function;routine urine;routine blood; | — |
Countries
China
Contacts
Public ContactZhaoyan Liu
Department of Nutrition, School of Public Health, Sun Yat-Sen University
Outcome results
None listed