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Clinical comparison of separation surgery combined with intraoperative radiotherapy, separation surgery combined with postoperative radiotherapy and traditional separation surgery in the treatment of spinal metastasis

Clinical comparison of separation surgery combined with intraoperative radiotherapy, separation surgery combined with postoperative radiotherapy and traditional separation surgery in the treatment of spinal metastasis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088176
Enrollment
Unknown
Registered
2024-08-13
Start date
2023-03-23
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal metastases

Interventions

traditional separation Operation Group:Only spinal metastases were isolated
separation operation combined with intraoperative radiotherapy group:The spinal metastases were isolated first and local radiotherapy was given during the operation
separation operation combined with postoperative radiotherapy group :The spinal metastatic tumor was isolated first, and the follow-up radiotherapy plan was made by the radiotherapy doctor after the o

Sponsors

Army Medical Center of PLA
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Spinal metastasis of solid malignant tumor confirmed by preoperative examination or postoperative pathology; (2) spinal metastases cause spinal instability; (3) intractable pain that is ineffective in non-surgical treatment of spinal metastases; (4) spinal metastases leading to progressive neurological dysfunction; (5) spinal metastases cause compression of the spinal cord; (6) Life expectancy is more than 3~6 months.

Exclusion criteria

Exclusion criteria: (1) benign tumors of the spine; (2) asymptomatic spinal metastases; (3) Other uncontrolled serious medical diseases; (4) Combined mental and cognitive disorders; (5) Cachexia and other functional failure of important organs cannot tolerate radiotherapy; (6) Severe cardiopulmonary disease or other inability to tolerate surgery; (7) Unwillingness or inability to participate in treatment and postoperative follow-up.

Design outcomes

Primary

MeasureTime frame
Pain index;Oswestry Disability Index;spinal instability neoplastic score;

Secondary

MeasureTime frame
Karnofsky;

Countries

China

Contacts

Public ContactLiu Mingyong

Army Medical Center of PLA

mingyong_liu@163.com+86 136 7765 0038

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026