Patients undergoing hysteroscopic surgery under general anesthesia without intubation
Conditions
Interventions
Experimental group (Part 1):Different dose of remimazolam combined with esketamine
Control group (Part 2):Propofol combined with esketamine
Experimental group (Part 2):Remimazolam tosilate combined with esketamine
Sponsors
Zhuji People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) perform hysteroscopic surgery under general anesthesia without intubation, 2) Aged 18-60 years old, 3) had no respiratory infection for at least a week,4) ASA I-III, 5) BMI 18-30 kg/m 2, 6) No difficult airway was expected before surgery.
Exclusion criteria
Exclusion criteria: 1) refused to participate in the study; 2) allergic or contraindication to benzodiazepines, propofol, esketamine or their components; 3) preoperative hepatic and renal dysfunction or other serious systemic diseases; 4) had a history of psychotropic drugs or sedative-hypnotic drugs use; 5) operation time exceeding 30 minutes or transfer to tracheal intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED90 of remimazolam combined with esketamine (Part 1);Time from immediate induction to loss of consciousness (Part 2); | — |
Secondary
| Measure | Time frame |
|---|---|
| Total dose of remimazolam (Part 1);Time to fall asleep (Part 1);Postoperative VAS pain score (Part 2);Postoperative complications (Part 2);Postoperative depression (Part 2);Perioperative hemodynamics indicators (Part1 and 2);Perioperative adverse events (Part1 and 2);Anesthesia time, Operation Time, Recovery time (Part1 and 2); | — |
Countries
China
Contacts
Public ContactHuang Xiaolin
Zhuji People's Hospital
Outcome results
None listed