obseity
Conditions
Interventions
Adjusted body weight group:General anesthesia was induced by continuous intravenous infusion of remimazolam tosylate at a rate of 12 mg/kg/h based on the adjusted body weight.
Total body weight group:General anesthesia was induced by continuous intravenous infusion of remimazolam tosylate at a rate of 12 mg/kg/h based on the total body weight.
Lean body weight group:General anesthesia was induced by continuous intravenous infusion of remimazolam tosylate at a rate of 12 mg/kg/h based on the lean body weight.
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~65 years old. 2.ASA class I to II. 3. An elective operation is planned for intuotracbation under general anesthesia and establishing venous access in the upper limb. 4.BMI=30kg/m2. 5.Mallampati class I to II. 6. Informed consent signed by the patient himself or his legally authorized representative.
Exclusion criteria
Exclusion criteria: 1. Cardiopulmonary disease, severe cardiac insufficiency (preoperative LVEF<50% or NYHA Grade IV), severe liver dysfunction (Child-Pugh Grade C), severe renal dysfunction (requiring dialysis treatment). 2.The preoperative medication regimen comprises benzodiazepines and opioids. 3. With a history of difficult airway (modified Mallampati score level III or IV) or difficult tracheal intubation, selective awake fiber tracheal intubation is planned. 4.History of neurological or psychiatric disorders or utilization of psychotropic medications. 5. Patients who used remimazolam and experimental anesthetics with caution or contraindication. 6.Received general anesthesia within 14 days prior to enrollment or had participated in other drug clinical trials within the preceding 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of general anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse events during anesthesia induction;Consumption of remimazolam tosylate ;The correlation betweenTBW,ABW,LBW, and consumption of remimazolam tosylate;Hemodynamic parameters during anesthesia induction (heart rate, blood pressure);the minimum pulse oxygen saturation;The bispectral index;The time of loss of consciousness; | — |
Countries
China
Contacts
Public ContactXin Zhao
Department of Anesthesiology, the Second Hospital, Cheeloo College of Medicine, Shandong University
Outcome results
None listed