Atrial fibrillation
Conditions
Interventions
HFrEF without AF:Oral SGLT2i
HFrEF with AF:Oral SGLT2i
Sponsors
Qinghai Cardio-Cerebrovascular Specialty Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1)Inclusion criteria of HFrEF: LVEF=40% and be hospitalized or outpatient visits because of heart failure (NYHA II-IV) , while no evidence of atrial fibrillation in the medical history; (2)Inclusion criteria of HFrEF + atrial fibrillation: LVEF=40% and be hospitalized or outpatient visits because of atrial fibrillation or heart failure (NYHA II-IV) , while diagnosed with atrial fibrillation by ECG, holter or wearable devices in the medical history. (3) Sign informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with ACS, cardiomyopathy, other severe arrhythmia besides atrial fibrillation, tumor, severe liver and kidney dysfunction, thyroid disease, massive pericardial effusion. (2) valvular atrial fibrillation. (3) PCI, CABG or CIED patients. (4) Intestinal dysfunction, antibiotic or probiotic users. (5) Urinary tract infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composite cardiovascular outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| epicardial adipose tissue ;gut microbiota ;metabolites; | — |
Countries
China
Contacts
Public ContactYu-Lan Ma
Qinghai Cardio-Cerebrovascular Specialty Hospital/Qinghai High Altitude Medical Research Institute
Outcome results
None listed