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The effect of remimazolam or dexmedetomidine combined with propofol on respiration and hemodynamics in heart disease patients undergoing transesophageal echocardiography: a prospective randomized study

The effect of remimazolam or dexmedetomidine combined with propofol on respiration and hemodynamics in heart disease patients undergoing transesophageal echocardiography: a prospective randomized study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088103
Enrollment
Unknown
Registered
2024-08-12
Start date
2024-09-01
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular disease

Interventions

R group:20 minutes before TEE examination, patients in group R received a loading dose of 0.1 mg/kg of remdesilam, which was pumped out within 10 minutes. Subsequently, continuous intravenous infusion
D group:20 minutes before TEE examination, the loading dose of dexmedetomidine (0.5 µ g/kg) in group D was pumped for 10 minutes, and the Dex maintenance dose was 0.4 µ g/kg/h until the end of the ope

Sponsors

Shifang people's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Male or female, aged 18 to 80, American Society of Anesthesiologists ASA grades I to III.

Exclusion criteria

Exclusion criteria: Including patients with severe heart disease (complex congenital heart disease, heart failure, and severe arrhythmia), pulmonary dysfunction, or any other disease that may hinder outpatient TEE surgery; Any patient with oral to gastric pathological conditions that may hinder TEE insertion and transmission; Body mass index>30; Pregnant; Hemorrhagic diseases; Drug abuse or frequent use of painkillers; And patients who are allergic to research drugs. In addition, patients who are unable to communicate and those who refuse to provide informed consent are also excluded.

Design outcomes

Primary

MeasureTime frame
Ramsay score;VAS score;Patient satisfaction rating;Steward's sobriety rating;

Secondary

MeasureTime frame
Doctor's satisfaction rating for anesthesia;Perioperative complications;

Countries

China

Contacts

Public ContactLin Zeng

Shifang People's Hospital

343329636@qq.com+86 152 8147 0503

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026