periodontitis
Conditions
Interventions
Healthy testee group:None
Periodontitis patient group:None
Sponsors
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Periodontitis, West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. for healthy testees, the inclusion criteria are: a) no severe periodontal pocket (= 4 mm) detected while bleed-on-probe sites less than 10%; b) with no systematic pathology, and aged between 18 and 60 years. 2. for periodontal patients, the inclusion criteria are: a) having 20 or more teeth; b) with periodontitis at stage II~IV; c) not a smoker; d) with no systematic pathology, and aged between 18 and 60 years.
Exclusion criteria
Exclusion criteria: 1. for healthy testees, the exclusion criteria are: a) significant clinical attachment loss (=3mm) detected by radiographic records or clinical examination; b) currently receiving or have ever received treatment that could affect their immune status in the last 6 months; c) currently using or have ever used antibiotics in the last 6 months; d) for women, not being pregnant. 2. for periodontal patients, the exclusion criteria are: a) periodontal treatment performed in the last 6 months; b) currently receiving or have ever received treatment that could affect their immune status in the last 6 months; c) currently using or have ever used antibiotics in the last 6 months; d) for women, not being pregnant; e) subjective rejection to periodontal nonsurgical treatments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor-a;Interleukin-1ß;Interleukin-6;Interleukin-17;Lipopolysaccharides;Interferon-?;Matrix metalloproteinase-8;C-reactive protein; | — |
Countries
China
Contacts
Public ContactGuo Shujuan
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Periodontitis, West China Hospital of Stomatology, Sichuan University
Outcome results
None listed