post-stroke cognitive impairment
Conditions
Interventions
preconditioning of iTBS group:Administer pre regulated transcranial direct current stimulation (tDCS) to the cathode, followed by iTBS stimulation and cognitive rehabilitation training.
iTBS group:Provide false cathode tDCS stimulation pre regulation+iTBS+cognitive rehabilitation training
Control group:Provide false cathode tDCS pre regulation+iTBS false stimulation+cognitive rehabilitation training
Sponsors
Xuzhou Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The diagnosis meets the diagnostic criteria for post-stroke cognitive impairment (PSCI) as outlined in the "Expert Consensus on Post Stroke Cognitive Impairment Management 2021" published by the Chinese Stroke Association and the Expert Committee on Post Stroke Cognitive Impairment Management in 2021. The MoCA score is less than 26 points and = 6 points; (2) Age range: 40-75 years old, all underwent head CT and MRI examinations; (3) Having sufficient visual and auditory resolution to undergo neuropsychological testing and other assessments; (4) First onset, within 6 months after stroke, with stable vital signs; (5) Right handed (6) subjects and/or guardians provide informed consent and sign a consent form, which has been approved by the Ethics Committee of Xuzhou Rehabilitation Hospital.
Exclusion criteria
Exclusion criteria: (1) Patients with cognitive impairment caused by various reasons other than stroke; (2) Severe dysfunction of important organs such as the heart, liver, kidneys, and lungs; (3) Patients with acute massive cerebral infarction or unabsorbed cerebral hemorrhage; (4) History of alcohol or drug abuse or dependence within the past 2 years; (5) Researchers believe that subjects who cannot follow the research procedure to complete the experiment; (6) Intracranial metal implants, magnetic plates, pacemakers, or skull defects; (7) Personal or family history of epilepsy, psychiatric history; (8) Patients with combined intracranial infection or open wounds or inflammation in the local skin of the treatment site; (9) Malignant tumors and pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Loewenstein Occupational Therapy Cognitive Assessment(LOTCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment(MoCA);Oxyhemoglobin and deoxyhemoglobin concentrations;Relative power ratio of frequency band;Event related potential -P300 latency and amplitude; | — |
Countries
China
Contacts
Public ContactShiyan Wang
Xuzhou Rehabilitation Hospital;Xuzhou Central Hospital
Outcome results
None listed